Summary: The target of Rapamycin complex1 (TORC1) senses and integrates several environmental signals, including amino acid (AA) availability, to regulate cell growth.Folliculin (FLCN) is a tumor suppressor (TS) protein in renal cell carcinoma, which paradoxically activates TORC1 in response to AA supplementation.Few tractable systems for modeling
Glen A Doherty, Mark A PeppercornCenter for Inflammatory Bowel Disease, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston MA, USAAbstract: 5-aminosalicyclates (5-ASA) remain a key first-line therapy for patients with ulcerative colitis (UC).A range Horse Saddles of 5-ASA preparations is available and Eudragit-S® coated
The maximally extracted endophallus of Valgus Fusewire hemipterus (Linnaeus, 1758) is described and illustrated for the first time.The endophallus is membranous, asymmetrical and divided into three discernible sections.Border between sections is indistinct, without strong constrictions.The first section is a small almost symmetrical chamber with tw
Gap junctions are intercellular channels which connect adjacent cells and allow direct exchange of molecules of low molecular weight between them.Such a communication has been described as fundamental in many systems due to its importance in coordination, proliferation and differentiation.Recently, it has been shown that gap junctional intercellula